A Concise Synthesis of the 1,6-Disubstituted Eudesmane Sesquiterpene Carbon Skeleton
نویسندگان
چکیده
The eudesmane sesquiterpenes are an important class of natural products, with relevant biological activities. Although these compounds can be substituted at practically all the carbon atoms, there is current interest for examples substituted at both C-1 and C-6 (see Schemes 1 and 2). In this short report we present a new methodology for the concise synthesis of the 1,6-disubstituted eudesmane carbon skeleton.
منابع مشابه
Neojaponicone A, a bioactive sesquiterpene lactone dimer with an unprecedented carbon skeleton from Inula japonica.
Five new dimeric sesquiterpene lactones, neojaponicone A (1) and japonicones M-P (2-5) were isolated from the aerial part of Inula japonica. Neojaponicone A (1) has an unprecedented carbon skeleton with an unusual valerolactone system formed between a guaianolide and an eudesmane. The structure and absolute configuration of 1 were established by extensive analysis of spectroscopic data and comp...
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